DNA Repair and Resistance to Cancer Therapy

نویسندگان

  • António S. Rodrigues
  • Bruno Costa Gomes
  • Célia Martins
  • Marta Gromicho
  • Nuno G. Oliveira
  • Patrícia S. Guerreiro
  • José Rueff
چکیده

Humans are constantly exposed to diverse chemical and physical agents that have the potential to damage DNA, such as reactive oxygen species (ROS), ionizing radiation (IR), UV light, and various environmental, dietary or pollutant chemical agents. The integrity and survival of a cell is critically dependent on genome stability, and cells possess multi‐ ple pathways to repair these DNA lesions. These pathways are diverse and target differ‐ ent types of lesions.

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تاریخ انتشار 2013